콘텐츠 본문
논문 해외 국제전문학술지(SCI급) Anti-HIV-1 efficacy of extracts from medicinal plants
- 학술지 구분 국제전문학술지(SCI급)
- 게재년월 2010-04
- 저자명 박정호
- 학술지명 JOURNAL OF MICROBIOLOGY
- 발행처명 MICROBIOLOGICAL SOCIETY KOREA
- 발행국가 해외
- 논문언어 외국어
- 전체저자수 8
논문 초록 (Abstract)
The anti-HIV-1 activities of butanol, hexane, chloroform and water extracts from four widely used folk medicinal plants (Sophora flavescens, Tulipa edulis, Herba ephedra, and Pachyma hoelen Rumph) were evaluated in this study. The hexane extract of Pachyma hoelen Rumph, PH-4, showed effective inhibition against HIV-1. The 50% effective concentration (EC50) of PH-4 was 37.3 mu g/ml in the p24 antigen assay and 36.8% in the HIV-1 recombinant RT activi ty test (at 200 mu g/ml). In addition, the PH-4 showed the protective effect on the infected MT-4 cells, with a 58.2% rate of protection. The 50% cytotoxic concentration (CC50) of PH-4 was 100.6 mu g/ml. These res ults suggest that PH-4 from Pachyma hoelen Rumph might be the candidat e for the chemotherapy agent against HIV-1 infection with further s tudy.
