콘텐츠 본문
논문 해외 국제전문학술지(SCI급) Proliferating Neural Progenitors in the Developing CNS of Zebrafish Require Jagged2 and Jagged1b
- 학술지 구분 국제전문학술지(SCI급)
- 게재년월 2010-08
- 저자명 박정호
- 학술지명 MOLECULES AND CELLS
- 발행처명 KOREAN SOC MOLECULAR CELLULAR BIOLOGY
- 발행국가 해외
- 논문언어 외국어
- 전체저자수 7
논문 초록 (Abstract)
In the central nervous system (CNS), giving rise to the diversity and the complexity of neurons is the spatial and temporal differentiation of neural stem cells and/or neural precursors. Here, we investigated the role of Jagged-mediated Notch signaling in the maintenance and differentiation of progenitor cells during late neurogenesis by analyzing the expression patterns of zebrafish jagged homologue s, and by injecting their morpholinos. Expression of both jagged2 and jagged1b mRNA in the CNS suggested that they might be involved in contr ol of differentiating neural progenitors in which they are involved later in development. In Jagged2 and Jagged1b knock-down embryos, the overall rate of cell division dramatically decreased, and the ectopi c VeMe neurons were generated. The results suggest that Jagged-Notc h signaling plays a critical role in the maintenance of proliferating ne ural precursors, and that the generation of late-born neurons, es pecially VeMe neurons, is regulated by the interplay between Jagged2 and Jagged1b.
