콘텐츠 본문
논문 해외 국제전문학술지(SCI급) Comparison of Newly Generated Doublecortin-immunoreactive Neuronal Progenitors in the Main Olfactory Bulb among Variously Aged Gerbils
- 학술지 구분 국제전문학술지(SCI급)
- 게재년월 2010-10
- 저자명 박정호
- 학술지명 NEUROCHEMICAL RESEARCH
- 발행처명 SPRINGER/PLENUM PUBLISHERS
- 발행국가 해외
- 논문언어 외국어
- 전체저자수 10
논문 초록 (Abstract)
In the present study, we investigated age-related differences in neuronal progenitors in the gerbil main olfactory bulb (MOB) usi ng doublecortin (DCX), a marker for neuronal progenitors which differentiate into neurons in the brain. No difference in t he number of neuronal nuclei (NeuN)-immunoreactive neurons was found in the MOB at variously aged gerbils. At postnatal month (PM) 1, DCX imm unoreaction was detected in all layers of the MOB except for the olfac tory nerve layer. Atthis time point, DCX-immunoreactive cells (neuro nal progenitors) were very abundant; however, they did not hav e fully developed-processes. From PM 3, the number of DCX-immunore active neuronal progenitors was decreased with age. At PM 6, DCX-immunoreactive cells showed very well-developed p rocesses. In western blot analysis, DCX protein level in the MOB w as highest at PM 1. Thereafter, levels of DCX protein were decreased w ith age. In the subventricular zoneof the lateral ventricle, the num ber of Ki-67-immunoractive cells (proliferating cells) was a lso significantly decreased with age. In addition, increases of alpha-synuclein-immunoreactive structures wer e observed in the MOB with age. These results suggest that decrease in D CX-immunoreactive neuronal progenitors and its protein levels in the MOB with age may be associated with reduction of cell proliferati on in the SVZ and with an increase in alpha- synuclein in the MDS
