콘텐츠 본문
논문 해외 국제전문학술지(SCI급) COMPARISON OF PHOSPHORYLATED EXTRACELLULAR SIGNAL-REGULATED KINASE 1/2 IMMUNOREACTIVITY IN THE HIPPOCAMPAL CA1 REGION INDUCED BY TRANSIENT CEREBRAL ISCHEMIA BETWEEN ADULT AND AGED GERBILS
- 학술지 구분 국제전문학술지(SCI급)
- 게재년월 2011-04
- 저자명 박정호
- 학술지명 CELLULAR AND MOLECULAR NEUROBIOLOGY
- 발행처명 SPRINGER/PLENUM PUBLISHERS
- 발행국가 해외
- 논문언어 외국어
- 전체저자수 10
논문 초록 (Abstract)
In this study, the authors examined the difference of phosphorylated extracellular signal-regulated kinase 1/2 (pERK1/2) in the hippocamp al CA1 region (CA1) between adult and aged gerbils after 5 min of transient cerebral ischemia. Delayed neuronal death in the CA1 of the aged group was much slower than that in the adult group after ischemia/reperfusion (I/R). pERK1/2 immunoreaction was observ ed in the CA1 region of the sham-operated adult gerbil. pERK1/2 immunor eactivity and protein levels in the ischemic CA1 region of the adult gr oup were markedly increased 4 days after I/R, and then reduced up to 1 0 days after I/R. In contrast, pERK1/2 immunoreaction was hardly det ected in the CA1 region of sham-operated aged gerbils, and the immunor eactivity increased from 1 day after the ischemic insult, and still obs erved until 10 days post-ischemia. In addition, pERK1/2-immunoreact ion was expressed in astrocytes in the ischemic CA1 region: The expre ssion in the ischemia-operated aged gerbils was later than that in the ischemia-operated adult gerbils. These results indicate that different patterns of ERK1/2 immunoreactivity may be associated with d ifferent processes of delayed neuronal death in adult and aged animal s.
