콘텐츠 본문
논문 해외 국제전문학술지(SCI급) COMPARISON OF GLUCOCORTICOID RECEPTOR AND IONIZED CALCIUM-BINDING ADAPTER MOLECULE 1 IMMUNOREACTIVITY IN THE ADULT AND AGED GERBIL HIPPOCAMPUS FOLLOWING REPEATED RESTRAINT STRESS
- 학술지 구분 국제전문학술지(SCI급)
- 게재년월 2011-06
- 저자명 박정호
- 학술지명 NEUROCHEMICAL RESEARCH
- 발행처명 SPRINGER/PLENUM PUBLISHERS
- 발행국가 해외
- 논문언어 외국어
- 전체저자수 9
논문 초록 (Abstract)
Stress leads to changes in homeostasis and internal balance of the body and is known to be one of important factors in the development of several diseases. In the present study, we investigated changes i n glucocorticoid receptor (GR) and ionized calcium-binding adapter molecule 1 (Iba-1) immunoreactivity in the adult and aged gerbil hippocampus after chronicrestraint stress. Serum corticosterone level was much higher in both the stress-groups than the control group s. No neuronal death was found in all hippocampal subregions of the ad ult and aged gerbil after chronic restraint stress. GR immunoreactivity was decreased in both the adult and aged groups after repeated rest raint stress; however, GR immunoreactivity in the adult-stress-group was decreased much more than that in the aged-stress-group. Iba-1 immunoreactive microglia were hypertrophied and activated in the adult group after repeated restraint stress; in the aged-stress-gr oup, there was no any significant change in Iba-1 immunoreactive microg lia. In brief, level of GR, not Iba-1, in the hippocampus was much d ecreased in theadult gerbil compared to the aged gerbil following chron ic restraint stress.
