콘텐츠 본문
논문 해외 국제전문학술지(SCI급) TIME COURSE OF POSTNATAL DISTRIBUTION OF DOUBLECORTIN IMMUNOREACTIVE DEVELOPING/MATURING NEURONS IN THE SOMATOSENSORY CORTEX AND HIPPOCAMPAL CA1 REGION OF C57BL/6 MICE
- 학술지 구분 국제전문학술지(SCI급)
- 게재년월 2011-07
- 저자명 박정호
- 학술지명 CELLULAR AND MOLECULAR NEUROBIOLOGY
- 발행처명 SPRINGER/PLENUM PUBLISHERS
- 발행국가 해외
- 논문언어 외국어
- 전체저자수 9
논문 초록 (Abstract)
In this study, we observed neuroblast differentiation in the somatosensory cortex (SSC) and hippocampal CA1 region (CA1), which is vulnerable to oxidative stress, of the mouse at various earl y postnatal days (P) 1, 7, 14, and 21 using doublecortin (DCX, a marker for neuroblasts). Cresyl violet and NeuN (Neuronal Nuclei) stai ning showed development of layers as well as neurons in the SSC and CA1 . At P1, DCX-positive neuroblasts expressed strong DCX immunoreactiv ity in both the SSC and CA1. Thereafter, DCX immunoreactivity was decre ased with time. At P7, many DCX-immunoreactive neuroblasts were well detected in the SSC and CA1. At P14, some DCX-positive neuroblasts wer e found in the SSC and CA1: The immunoreactivity was weak. At P21, DC X immunoreactivity was hardly found in cells in the SSC and CA1. These results suggest that DCX-positive neuroblasts were signif icantly decreased in the mouse SSC and CA1 from P
