콘텐츠 본문
논문 해외 국제전문학술지(SCI급) NEUROPROTECTION OF A NOVEL SYNTHETIC CAFFEIC ACID-SYRINGIC ACID HYBRID COMPOUND AGAINST EXPERIMENTALLY INDUCED TRANSIENT CEREBRAL ISCHEMIC DAMAGE
- 학술지 구분 국제전문학술지(SCI급)
- 게재년월 2013-03
- 저자명 박정호
- 학술지명 PLANTA MEDICA
- 발행처명 GEORG THIEME VERLAG KG
- 발행국가 해외
- 논문언어 외국어
- 전체저자수 13
논문 초록 (Abstract)
We investigated effects of caffeic acid, syringic acid, and their synthesis on transient cerebral ischemic damage in the gerbil hippocampal CA1 region. In the 10 mg/kg caffeic acid-, syring ic acid-, and 20 mg/kg syringic-treated ischemia groups, we did not fin d any significant neuroprotection in the ischemic hippocampal CA re gion. In the 20 mg/kg caffeic acid- and 10 mg/kg caffeic acid-syringic acid- treated ischemia groups, moderate neuroprotection was found i n the hippocampal CA1 region. In the 20 mg/kg caffeic acid- syringi c acid- treated ischemia group, a strong neuroprotective effect was f oundin the ischemic hippocampal CA1 region: about 89% of hippocampal CA1 region pyramidal neurons survived. We also observedchanges i n glial cells (astrocytes and microglia) in the ischemic hippocampal CA1 region in all the groups. Among them, the distribution pattern of t he glial cells was only in the 20 mg/kg caffeic acid- syringic acid- treated ischemia group brief, 20 mg/kg caffeic acid-syringic acid s howed a strong neuroprotective effect with an inhibition of glia ac tivation in thehippocampal CA1 region induced by transient cerebral is chemia.
