콘텐츠 본문
논문 해외 국제전문학술지(SCI급) NEUROPROTECTIVE EFFECT OF A NEW SYNTHETIC ASPIRIN-DECURSINOL ADDUCT IN EXPERIMENTAL ANIMAL MODELS OF ISCHEMIC STROKE
- 학술지 구분 국제전문학술지(SCI급)
- 게재년월 2013-09
- 저자명 박정호
- 학술지명 PLOS ONE
- 발행처명 PUBLIC LIBRARY SCIENCE
- 발행국가 해외
- 논문언어 외국어
- 전체저자수 23
논문 초록 (Abstract)
Stroke is the second leading cause of death. Experimental animal models of cerebral ischemia are widely used for researching mechanisms of ischemic damage and developing new drugs for the prevention and treatment of stroke. The present study aimed to comparatively investigate neuroprotective effects of aspirin (ASA), decursi nol (DA) and new synthetic aspirin-decursinol adduct (ASA-DA) against transient focal and global cerebral ischemic damage. We found that tre atment with 20 mg/kg,not 10 mg/kg, ASA-DA protected against ischemia-in duced neuronal death after transient focal and global ischemic dam age, and its neuroprotective effect was much better than that of ASA or DA alone. In addition, 20 mg/kg ASA-DA treatment reduced the ischemia-induced gliosis and maintained antioxidants leve ls in the corresponding injury regions. In brief, ASA-DA, a new syn thetic drug, dramatically protected neurons from ischemic damage, and neuroprotective effects of ASA-DA may be closely related to the attenuation of ischemia-induced gliosis and maintenance of antioxidants.
