유기분자연구실

논문 초록 (Abstract)

Risperidone, an atypical antipsychotic drug, has been discovered to have some beneficial effects beyond its original effectiveness. The present study examines the neuroprotective effects of risperidone against ischemic damage in the rat and gerbil induced by transien t focal and global cerebral ischemia, respectively. The results sho wed that pre- and posttreatment with 4 mg/kg risperidone significantl y protected against neuronal death from ischemic injury. Many NeuN-immunoreactive neurons and a few F-J B-positive cells were found in the rat cerebral cortex and gerbil hippocampal CA1 regi on (CA1) in the risperidone-treated ischemia groups compared with thos e in the vehicle-treated ischemia group. In addition, treatment wit h risperidone markedly attenuated the activation of microglia in the ger bil CA1. On the other hand, we found that treatment with risperidone s ignificantly maintained the antioxidants levels in the ischemic gerbil CA1. Immunoreactivities of superoxide dismutases 1 and 2, cata lase, and glutathione peroxidase were maintained in the stratum pyr amidale of the CA1; the antioxidants were very different from those in t he vehicle-treated ischemia groups. In brief, our present fi ndings indicate that posttreatment as well as pretreatment with risperidone can protect neurons in the rat cerebral cortex and gerbi ls CA1 from transient cerebral ischemic injury and that the neuropro tective effect of risperidone may be relatedto attenuation of microgli al activation as well as maintenance of antioxidants. (c) 2014 Wiley P eriodicals, Inc.