콘텐츠 본문
논문 해외 국제전문학술지(SCI급) INHIBITION OF TYROSINASE ACTIVITY AND MELANIN PRODUCTION BY THE CHALCONE DERIVATIVE 1-(2-CYCLOHEXYLMETHOXY-6-HYDROXY-PHENYL)-3(4-HYDROXYMETHYL-PHENYL)-PROPENONE
- 학술지 구분 국제전문학술지(SCI급)
- 게재년월 2016-11
- 저자명 박정호
- 학술지명 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- 발행처명 ACADEMIC PRESS INC ELSEVIER SCIENCE
- 발행국가 해외
- 논문언어 외국어
- 전체저자수 6
논문 초록 (Abstract)
Abnormal accumulation of melanin pigments in the skin can be lead to hyperpigmentation disorders and melanoma. Melanin biosynthesis is ultimately regulated by the rate-limiting enzyme tyrosinase. In t he present study, we synthesized chalcone derivatives and identified 1-(2-cyclohexylmethoxy-6-hydroxyphenyl)-3-(4-hydroxymethyl-phenyl )-propenone (chalcone-21) as an anti-melanogenic substance in B16F10 mel anoma cells. Chalcone-21 strongly inhibited cellular melanin production and tyrosinase activity in B16F10 melanoma cells stimulated with a-melanocyte stimulating hormone (alpha-MSH) or protoporphyr in IX. In addition, the compound suppressed not only the expression of tyrosinase, tyrosinase-related protein-1 (TRP-1), TRP-2, and microphthalmia-associated transcription factor (MITF), but a lso the transcriptional activity of tyrosinase and MITE Our results demonstrated chalcone-21 to be an effective depigmenting ag ent. (C) 2016 Elsevier Inc. All rights reserved.
