콘텐츠 본문
논문 해외 국제전문학술지(SCI급) ANTICANCER ACTIVITY OF 2-AMINO-SUBSTITUTED-1,4-NAPHTHOQUINONE DERIVATIVES IN OVARIAN CANCER CELLS
- 학술지 구분 국제전문학술지(SCI급)
- 게재년월 2017-12
- 저자명 박정호
- 학술지명 BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- 발행처명 KOREAN CHEMICAL SOC
- 발행국가 해외
- 논문언어 외국어
- 전체저자수 6
논문 초록 (Abstract)
2-Amino-substituted-1,4-naphthoquinone derivatives (10-17) were synthesized from coupling reaction between 1,4-dihydroxynaphtha lene and amines in the presence of catalyst CeCl(3)(.)7H(2)O. Their anti cancer activity was evaluated by using three ovarian cancer cells (A27 80, SKOV3, and OVCAR3). Among the eight compounds, compound 13 cont aining metal chelating moiety had a relatively potent cytotoxic activi ty (IC50 < 10 M) on all three ovarian cancer cells.
